Unopened compounded semaglutide lasts 28-30 days in the fridge (2°C-8°C or 36°F-46°F).
Comounded semaglutide remains stable for up to 1 month when refrigerated and unopened. After opening, its shelf life shortens to 7-14 days depending on formulation. Always verify expiration dates from your provider, as stability varies by compounding methods and preservatives used.
Key Factors Affecting Shelf Life
- Preservatives: Multi-dose vials with preservatives (e.g., benzyl alcohol) last longer than single-dose.
- Temperature: Must stay between 2°C-8°C (36°F-46°F); freezing or heat degrades it.
- Light exposure: Store in original packaging to avoid UV damage.
- Compounding standards: USP <797> compliance ensures longer stability.
Shelf Life Comparison: Compounded vs. Brand-Name vs. Reconstituted
| Type | Unopened (Fridge) | Opened (Fridge) | Room Temp (After Opening) |
|---|---|---|---|
| Comounded semaglutide | 28-30 days | 7-14 days | Not recommended |
| Brand-name semaglutide (prefilled pen) | Up to 56 days | 28-56 days | 21-56 days (varies by product) |
| Reconstituted semaglutide (powder + diluent) | 24-48 hours | 24 hours max | 4-8 hours |
Signs Your Semaglutide Has Expired
- Cloudiness or particles in the liquid (should be clear/colorless).
- Color changes (yellowing or darkening).
- Unusual odor (should be odorless).
- Reduced effectiveness (e.g., less appetite suppression).
How to Maximize Refrigerated Stability
- Keep in the main fridge body (not door) to avoid temperature fluctuations.
- Use a thermometer to monitor fridge temps (aim for 4°C/39°F).
- Avoid repeated opening of the fridge door for long periods.
- Store in original packaging until use to block light.
- Never use if left at room temp for >24 hours (compounded versions).
What to Do If You Suspect Spoilage
- Do not use. Expired or contaminated semaglutide may cause infection or lose potency.
- Contact your provider for a replacement if unopened and stored correctly but expired prematurely.
- Dispose of via a medication take-back program or mix with coffee grounds/sealed bag for trash disposal.